不同来源燕麦对ApoE-/- 小鼠降血脂功能的研究

Effects of Oats from Different Sources on Hypolipidemic Function in ApoE-/- Mice

中文关键词: 燕麦  ApoE-/- 小鼠  降血脂  肝脏保护

英文关键词: oat  ApoE-/- mice  hypolipidemic function  liver protection

中文摘要:

      为研究不同来源燕麦对高脂饲喂的ApoE-/- 小鼠降血脂功能的影响，将40 只雄性ApoE-/- 小鼠按照平均体重随机分为5 组，即常规饮食(Chow)组、高脂饮食(HFD)组、燕麦1 组(OAT-1)、燕麦2 组(OAT-2)以及燕麦3 组(OAT-3)，每组8 只。实验0 w、4 w、8 w、12 w 时，分别测定小鼠血清总胆固醇(total cholesterol，TC)、LDL胆固醇(LDL cholesterol，LDL-c)、甘油三酯(triglycerides，TG)、HDL 胆固醇(HDL cholesterol，HDL-c) 和VLDL胆固醇(VLDL cholesterol，VLDL-c)水平；12 w 后同时观察肝组织损伤变化情况。其中，3 组燕麦组均能够显著减少ApoE-/- 小鼠血清中TC、LDL-c、TG 和VLDL-c 的含量，说明3 组燕麦均具有良好的降血脂作用，OAT-3 组降血脂效果更加明显。病理学检测结果显示，3 组燕麦组均具有减少高脂饲喂的ApoE-/- 小鼠肝脏中脂质沉积的作用。燕麦饲喂后对高脂饲喂的ApoE-/- 小鼠具有显著降低血脂及降低肝损伤作用。

英文摘要:

      In order to study the effects of oats from different sources on the hypolipidemic function of high-fat-fed ApoE-/- mice, 40 male ApoE-/- mice were randomly divided into 5 groups of 8 mice each with mean body weight, which were normal control group (Chow), high-fat model group (HFD), oat 1 group (OAT-1), oat 2 group (OAT-2) and oat 3 group (OAT-3). The total cholesterol (TC), LDL cholesterol (LDL-c), triglycerides (TG), HDL cholesterol (HDL-c) and VLDL cholesterol (VLDL-c) levels in serum of mice were measured respectively, after 0, 4, 8 and 12 weeks, and the changes of liver injury were observed after 12 weeks. The serum levels of TC, LDL-c, TG and VLDL-c in ApoE-/- mice were significantly reduced in the three oat groups, indicating that the three oat groups have good effects on the hypolipidemic function in ApoE-/- mice, and the OAT-3 group decreased the serum lipid contents more than OAT-1 group. The pathological examination results showed that the three oat groups all had the effect of reducing lipid deposition in the liver of high-fat-fed ApoE-/- mice. Oats can significantly reduce blood lipids and liver injury in high-fat-fed ApoE-/- mice.